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Table 1 In vitro minimal inhibitory concentration (MIC) values of NFAP2, NFAP and conventional antifungal agents for the investigated fungal isolates

From: NFAP2, a novel cysteine-rich anti-yeast protein from Neosartorya fischeri NRRL 181: isolation and characterization

Fungus MIC (µg ml−1)
NFAP2 NFAP AMB ITC FLC TRB CSP
Yeasts
 Candida albicans ATCC 10231 0.781 >200 8 >64 >64 64 16
 Candida glabrata CBS 138 0.391 >200 8 >64 >64 64 16
 Candida guilliermondii CBS 566 0.391 >200 4 2 8 16 16
 Candida krusei CBS 573 1.563 >200 8 2 >64 64 16
 Candida lusitaniae CBS 6936 0.781 >200 8 16 >64 16 16
 Candida parapsilosis CBS 604 0.391 >200 8 2 >64 16 32
 Candida tropicalis CBS 94 0.391 >200 8 >64 >64 >64 8
 Saccharomyces cerevisiae SZMC 0644 0.195 >200 4 2 64 >64 16
 Schizosaccharomyces pombe SZMC 0142 0.391 >200 4 8 64 >64 16
Filamentous fungi
 Aspergillus nidulans FGSC A4 >25 200 >64 4 >64 8 >64
 Aspergillus niger SZMC 601 >25 50 8 8 >64 16 >64
 Rhizomucor mieheii CBS 360.92 >25 >200 2 1 16 8 8
  1. MIC was determined after 24 h (yeasts and R. miehei CBS 360.92) and 48 h (Aspergillus spp.) of incubation. Abbreviations: AMB amphotericin B, CSP caspofungin, FLC fluconazole, ITC itraconazole, NFAP Neosartorya fischeri antifungal protein, NFAP2 Neosartorya fischeri antifungal protein 2, TRB terbinafine