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Fig. 5 | AMB Express

Fig. 5

From: Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice

Fig. 5

Therapeutic effects in the immunocompetent BALB/c mice with highly aggressive tumors elicited by ST8-mediated secretion of Endostatin. a Potent treatment of large established tumors with ST8/pSEndo. CT26 murine tumor cells were implanted subcutaneously into BALB/c mice, and then the mice bearing large tumors received intravenous injections of the indicated strains. Values are expressed as mean ± SD (n = 5). **P < 0.01 compared with vector control ST8/pSGFP. b Tumor proliferation was examined by Ki67 expression of primary tumors from ST8/pSGFP and ST8/pSEndo treated mice. Scale bar 100 μm. c No apparent damages were found in any of the organs in the ST8/pSEndo treatment group. Scale bar 100 μm

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