Fig. 3From: Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in miceST8/pSEndo secretes recombinant SopA_Endostatin to target cells through the type III secretion system. a Diagram of plasmid pSEndo used in this study. b Plasmid pSGFP and pSEndo were introduced into ST8. ST8/pSEndo cells were exposed to cultured CT26 cells and the presence of fusion protein in supernatants examined as described above. c Endothelial cell tube formation assay showed interference of network assembly of HUVEC cells on Matrigel in ST8/pSEndo conditioned medium (right) compared with ST8/pSGFP conditioned medium (left)Back to article page