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Table 1 Fermentation profiles of high-SAM-producing (Kyokai 6) and laboratory (S288C) strains in the presence of glucose with or without l-methionine

From: Metabolome analysis of Saccharomyces cerevisiae and optimization of culture medium for S-adenosyl-l-methionine production

Strain Kyokai 6 S288C
l-Methionine + +
SAM production (mg L−1) 7.5 ± 0.4 177.6 ± 4.0 6.3 ± 0.1 62.6 ± 0.9
Biomass (g CDW L−1) 6.7 ± 0.04 5.6 ± 0.06 5.5 ± 0.05 5.0 ± 0.05
SAM content (mg g CDW−1) 1.1 ± 0.01 31.8 ± 1.0 1.1 ± 0.01 12.5 ± 0.2
Ethanol (g L−1) 17.8 ± 0.5 20.0 ± 0.1 19.5 ± 0.2 20.7 ± 0.1
pH 5.7 ± 0.02 5.3 ± 0.05 6.0 ± 0.03 5.4 ± 0.03
  1. All data were obtained from the averages of three independent experiments ± SD