|
Growth condition
|
IC50 (µM)
|
MIC (µM)
|
MBC (µM)
|
|---|
|
Planktonic growth
|
CPC: 0.6
|
CPC: 1.2
|
CPC: 2.5
|
|
CPB: 0.5
|
CPB: 0.6
|
CPB: 4.9
|
|
CPI: 0.7
|
CPI: 1.2
|
CPI: 4.9
|
|
Biofilm forming
|
CPC: 0.2
|
CPC: 0.4
|
CPC: 0.8
|
|
CPB: 0.2
|
CPB: 0.4
|
CPB: 0.8
|
|
CPI: 0.3
|
CPI: 0.4
|
CPI: 0.8
|
|
24 h biofilm
|
CPC: 24
|
CPC: 43
|
CPC: 172
|
|
CPB: 20
|
CPB: 43
|
CPB: 172
|
|
CPI: 32
|
CPI: 86
|
CPI: 172
|
- The antimicrobial activity of three halide salts of cetylpyridinium (CPC, CPB, and CPI) against S. mutans under different culture conditions (planktonic, biofilm forming, and 24 h biofilm) was measured by IC50, MIC, and MBC in a single experiment. For each condition, no significant effect was observed for the identity of the halide counter ion within the precision of these measurements
