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AMB Express

Table 1 Top sense-strand sequence of NP and PA siRNAs, the location of the target sequence in the corresponding NP or PA virus gene and siRNA specificity with the original AIV gene

From: Inhibiting avian influenza virus shedding using a novel RNAi antiviral vector technology: proof of concept in an avian cell model

Gene (bp region)

Sense strand sequence (5′–3′)

NP-siRNA

GGA TCT TAT TTC TTC GGA G-dTdT

H8N4 NP (1486–1504)

GGA TCT TAT TTC TTC GGA G

H6N2 NP (1453–1471)

GGA TCT TAT TTC TTC GGA G

PA-siRNA

GCA ATT GAG GAG TGC CTG A-dTdT

H8N4 PA (2077–2095)

GCA ATT GAG GAG TGC CTG A

H6N2 PA (2065–2083)

GCA ATT GAG GAG TGC CTG A

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