|
Test compounds
|
Substrate(s)
|
MIC/MBC
|
IC50
|
|---|
|
B. anthracis
|
E. faecalis
|
L. monocytogenes
|
S. aureus
|
HepG2
|
|---|
|
Ciproflaxin
|
na
|
0.07
|
0.52
|
1.56
|
0.68
|
nd
|
|
Tryptanthrin
|
na
|
>25
|
nd
|
nd
|
4.6
|
nd
|
|
SAB-R1
|
Ind(Ant)
|
>12.5
|
>12.5
|
>12.5
|
>12.5
|
nd
|
|
SAB-C10
|
5C
|
3.12/12.5
|
12.5
|
12.5
|
6.25/25
|
>100
|
|
SAB-J2
|
5F
|
6.25
|
12.5
|
12.5
|
3.12/12.5
|
49.2
|
|
SAB-J3
|
5B
|
1.56/12.5
|
0.78/>25
|
1.56/>25
|
1.56/12.5
|
>100a
|
|
SAB-J7
|
5C(Ant)
|
6.25
|
>25
|
>25
|
>25
|
nd
|
|
SAB-J11
|
Ind(Ant)
|
3.12/25
|
>25
|
>25
|
6.25
|
>100
|
|
SAB-J16
|
5B
|
6.25
|
12.5
|
25
|
12.5
|
nd
|
|
SAB-J19
|
4B(7C)
|
6.25
|
>25
|
25
|
6.25
|
nd
|
|
SAB-J20
|
6C
|
6.25
|
>25
|
>25
|
6.25
|
nd
|
|
SAB-J22
|
5F(1M)
|
6.25
|
>25
|
>25
|
>25
|
nd
|
|
SAB-J25
|
6C(7C)
|
3.12/25
|
12.5
|
25
|
6.25
|
>100a
|
|
SAB-J35
|
4B
|
6.25
|
>25
|
>25
|
>25
|
nd
|
|
SAB-J36
|
6C
|
6.25
|
25
|
>25
|
12.5
|
nd
|
|
SAB-J37
|
5B(6C)
|
3.12/25
|
12.5
|
12.5
|
6.25
|
>100a
|
|
SAB-J38
|
5C(Ant)
|
3.12/12.5
|
>25
|
25
|
6.25
|
>100
|
|
SAB-J39
|
5C(Ant)
|
6.25
|
>25
|
>25
|
6.25
|
>100
|
|
SAB-J45
|
5B(Ant)
|
1.6/3.3
|
3.1
|
6.3
|
3.1/12.5
|
>100
|
|
SAB-7f-R1
|
7F(Ant)
|
>12.5
|
>12.5
|
>125
|
3.1/>12.5
|
nd
|
|
SAB-J51
|
5F(7F)
|
0.88/4.69
|
1.95/>12.5
|
1.76/>12.5
|
1.17/>12.5
|
78.4a
|
|
SAB-J62
|
5F(Ant)
|
5.47/>12.5
|
>12.5
|
>12.5
|
5.47/>12.5
|
>100
|
|
SAB-J63
|
5B(Ant)
|
3.12/>12.5
|
>12.5
|
>12.5
|
5.4/>12.5
|
>100a
|
|
SAB-J65
|
5C(Ant)
|
2.15/>12.5
|
>12.5
|
>12.5
|
0.98/>12.5
|
>100
|
|
SAB-J69
|
5B(Ant)
|
3.52/>12.5
|
>12.5
|
>12.5
|
3.12/>12.5
|
>100
|
|
SAB-J76
|
6C(Ant)
|
0.78/2.34
|
2.73/>12.5
|
7.29/>12.5
|
2.15/12.5
|
43.8
|
|
SAB-J78
|
6C(Ant)
|
1.56/>12.5
|
>12.5
|
>12.5
|
3.9/>12.5
|
>100
|
|
SAB-J79
|
6C(Ant)
|
0.78/4.69
|
>12.5
|
>12.5
|
1.37/9.38
|
>100
|
|
SAB-J81
|
5B(Ant)
|
>7.29
|
>12.5
|
>12.5
|
1.37/>12.5
|
>100
|
|
SAB-J82
|
5B(Ant)
|
6.25
|
>12.5
|
>12.5
|
6.25
|
nd
|
|
SAB-J85
|
6C(Ant)
|
0.78
|
nd
|
nd
|
3.13
|
nd
|
- The most effective compound against each strain shown in italic font.
-
na not applicable, nd not determined.
- Substrate abbreviations: Ind indole, Ant anthranil, 4B 4-bromoindole, 5B 5-bromoindole, 5f 5-fluoroindole, 6F 6-fluoroindole, 7F 7-fluoroindole, 5C 5-chloroindole, 6C 6-chloroindole, 7C 7-chloroindole, 1M 1-methylindole.
-
aCompounds partially insoluble at concentration listed.
