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Table 1 MIC, MBC and IC50 values (µg/ml) for selected compounds

From: Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis

Test compounds Substrate(s) MIC/MBC IC50
B. anthracis E. faecalis L. monocytogenes S. aureus HepG2
Ciproflaxin na 0.07 0.52 1.56 0.68 nd
Tryptanthrin na >25 nd nd 4.6 nd
SAB-R1 Ind(Ant) >12.5 >12.5 >12.5 >12.5 nd
SAB-C10 5C 3.12/12.5 12.5 12.5 6.25/25 >100
SAB-J2 5F 6.25 12.5 12.5 3.12/12.5 49.2
SAB-J3 5B 1.56/12.5 0.78/>25 1.56/>25 1.56/12.5 >100a
SAB-J7 5C(Ant) 6.25 >25 >25 >25 nd
SAB-J11 Ind(Ant) 3.12/25 >25 >25 6.25 >100
SAB-J16 5B 6.25 12.5 25 12.5 nd
SAB-J19 4B(7C) 6.25 >25 25 6.25 nd
SAB-J20 6C 6.25 >25 >25 6.25 nd
SAB-J22 5F(1M) 6.25 >25 >25 >25 nd
SAB-J25 6C(7C) 3.12/25 12.5 25 6.25 >100a
SAB-J35 4B 6.25 >25 >25 >25 nd
SAB-J36 6C 6.25 25 >25 12.5 nd
SAB-J37 5B(6C) 3.12/25 12.5 12.5 6.25 >100a
SAB-J38 5C(Ant) 3.12/12.5 >25 25 6.25 >100
SAB-J39 5C(Ant) 6.25 >25 >25 6.25 >100
SAB-J45 5B(Ant) 1.6/3.3 3.1 6.3 3.1/12.5 >100
SAB-7f-R1 7F(Ant) >12.5 >12.5 >125 3.1/>12.5 nd
SAB-J51 5F(7F) 0.88/4.69 1.95/>12.5 1.76/>12.5 1.17/>12.5 78.4a
SAB-J62 5F(Ant) 5.47/>12.5 >12.5 >12.5 5.47/>12.5 >100
SAB-J63 5B(Ant) 3.12/>12.5 >12.5 >12.5 5.4/>12.5 >100a
SAB-J65 5C(Ant) 2.15/>12.5 >12.5 >12.5 0.98/>12.5 >100
SAB-J69 5B(Ant) 3.52/>12.5 >12.5 >12.5 3.12/>12.5 >100
SAB-J76 6C(Ant) 0.78/2.34 2.73/>12.5 7.29/>12.5 2.15/12.5 43.8
SAB-J78 6C(Ant) 1.56/>12.5 >12.5 >12.5 3.9/>12.5 >100
SAB-J79 6C(Ant) 0.78/4.69 >12.5 >12.5 1.37/9.38 >100
SAB-J81 5B(Ant) >7.29 >12.5 >12.5 1.37/>12.5 >100
SAB-J82 5B(Ant) 6.25 >12.5 >12.5 6.25 nd
SAB-J85 6C(Ant) 0.78 nd nd 3.13 nd
  1. The most effective compound against each strain shown in italic font.
  2. na not applicable, nd not determined.
  3. Substrate abbreviations: Ind indole, Ant anthranil, 4B 4-bromoindole, 5B 5-bromoindole, 5f 5-fluoroindole, 6F 6-fluoroindole, 7F 7-fluoroindole, 5C 5-chloroindole, 6C 6-chloroindole, 7C 7-chloroindole, 1M 1-methylindole.
  4. aCompounds partially insoluble at concentration listed.