Test compounds | Substrate(s) | MIC/MBC | IC50 | |||
---|---|---|---|---|---|---|
B. anthracis | E. faecalis | L. monocytogenes | S. aureus | HepG2 | ||
Ciproflaxin | na | 0.07 | 0.52 | 1.56 | 0.68 | nd |
Tryptanthrin | na | >25 | nd | nd | 4.6 | nd |
SAB-R1 | Ind(Ant) | >12.5 | >12.5 | >12.5 | >12.5 | nd |
SAB-C10 | 5C | 3.12/12.5 | 12.5 | 12.5 | 6.25/25 | >100 |
SAB-J2 | 5F | 6.25 | 12.5 | 12.5 | 3.12/12.5 | 49.2 |
SAB-J3 | 5B | 1.56/12.5 | 0.78/>25 | 1.56/>25 | 1.56/12.5 | >100a |
SAB-J7 | 5C(Ant) | 6.25 | >25 | >25 | >25 | nd |
SAB-J11 | Ind(Ant) | 3.12/25 | >25 | >25 | 6.25 | >100 |
SAB-J16 | 5B | 6.25 | 12.5 | 25 | 12.5 | nd |
SAB-J19 | 4B(7C) | 6.25 | >25 | 25 | 6.25 | nd |
SAB-J20 | 6C | 6.25 | >25 | >25 | 6.25 | nd |
SAB-J22 | 5F(1M) | 6.25 | >25 | >25 | >25 | nd |
SAB-J25 | 6C(7C) | 3.12/25 | 12.5 | 25 | 6.25 | >100a |
SAB-J35 | 4B | 6.25 | >25 | >25 | >25 | nd |
SAB-J36 | 6C | 6.25 | 25 | >25 | 12.5 | nd |
SAB-J37 | 5B(6C) | 3.12/25 | 12.5 | 12.5 | 6.25 | >100a |
SAB-J38 | 5C(Ant) | 3.12/12.5 | >25 | 25 | 6.25 | >100 |
SAB-J39 | 5C(Ant) | 6.25 | >25 | >25 | 6.25 | >100 |
SAB-J45 | 5B(Ant) | 1.6/3.3 | 3.1 | 6.3 | 3.1/12.5 | >100 |
SAB-7f-R1 | 7F(Ant) | >12.5 | >12.5 | >125 | 3.1/>12.5 | nd |
SAB-J51 | 5F(7F) | 0.88/4.69 | 1.95/>12.5 | 1.76/>12.5 | 1.17/>12.5 | 78.4a |
SAB-J62 | 5F(Ant) | 5.47/>12.5 | >12.5 | >12.5 | 5.47/>12.5 | >100 |
SAB-J63 | 5B(Ant) | 3.12/>12.5 | >12.5 | >12.5 | 5.4/>12.5 | >100a |
SAB-J65 | 5C(Ant) | 2.15/>12.5 | >12.5 | >12.5 | 0.98/>12.5 | >100 |
SAB-J69 | 5B(Ant) | 3.52/>12.5 | >12.5 | >12.5 | 3.12/>12.5 | >100 |
SAB-J76 | 6C(Ant) | 0.78/2.34 | 2.73/>12.5 | 7.29/>12.5 | 2.15/12.5 | 43.8 |
SAB-J78 | 6C(Ant) | 1.56/>12.5 | >12.5 | >12.5 | 3.9/>12.5 | >100 |
SAB-J79 | 6C(Ant) | 0.78/4.69 | >12.5 | >12.5 | 1.37/9.38 | >100 |
SAB-J81 | 5B(Ant) | >7.29 | >12.5 | >12.5 | 1.37/>12.5 | >100 |
SAB-J82 | 5B(Ant) | 6.25 | >12.5 | >12.5 | 6.25 | nd |
SAB-J85 | 6C(Ant) | 0.78 | nd | nd | 3.13 | nd |