Isolation, purification and characterization of novel antimicrobial compound 7-methoxy-2,2-dimethyl-4-octa-4′,6′-dienyl-2H-napthalene-1-one from Penicillium sp. and its cytotoxicity studies

AMB Express

Table 2 Comparison of MIC of butanolic extract and pure compound with two standard antibiotics

Microorganisms	MIC butanolic extract	MIC of compound	MIC of gentamicin	MIC of amphotericin B
S. aureus	0.1^c	2^b	1^a	ND
S. epidermidis	0.2^c	2^b	1^a	ND
K. penumoniae 1	0.1^c	1^b	0.19^a	ND
C. albicans	0.2^b	1^a	ND	ND
MRSA	0.5^c	5^b	0.19^a	99^d
P. aeruginosa	1^b	ND	10^a	ND
S. typhimurium 2	0.7^c	5^b	2^a	ND
Sh. flexneri	5^b	ND	2^a	ND
E. faecalis	5^b	ND	10^a	ND
E. coli	10^b	ND	1^a	ND
S. typhimurium 1	15^b	ND	1^a	ND
K. penumoniae 2	20^b	ND	1^a	ND

The values represents mean of three values, different lower case letters (a–c) show statistical significant (P ≤ 0.05) difference between columns.