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Table 1 Technologies used in the process to obtain recombinant glucagon and respective patents

From: Recombinant glucagon: a differential biological activity

Technology Patent number Patent year Patent expiration
pGEX4t-3 t vector US 5654176 1997 2017
GST Tag US 5654176 1997 2017
FLAG Tag US 4703004 1987 2007
BL21(DE3) strain US 5693489 1997 2017
Enterokinase Enzyme US 5665566 1997 2017
Glutathione Sepharore Resin US 5654176 1997 2017
Glucagen® US 5652216 1997* 2017
  1. *The first patent filed was in 1989. This is an evergreening patent, a type of patent with novel technology is added to previous one. Basso (2012)