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Table 1 Technologies used in the process to obtain recombinant glucagon and respective patents

From: Recombinant glucagon: a differential biological activity

Technology

Patent number

Patent year

Patent expiration

pGEX4t-3 t vector

US 5654176

1997

2017

GST Tag

US 5654176

1997

2017

FLAG Tag

US 4703004

1987

2007

BL21(DE3) strain

US 5693489

1997

2017

Enterokinase Enzyme

US 5665566

1997

2017

Glutathione Sepharore Resin

US 5654176

1997

2017

Glucagen®

US 5652216

1997*

2017

  1. *The first patent filed was in 1989. This is an evergreening patent, a type of patent with novel technology is added to previous one. Basso (2012)