0
|
LinBUT
| |
A
|
A
|
I
|
A
|
I
|
A
|
M
|
17 ± 0
|
9
|
2.0 ± 1
|
0.2
|
This studyb
|
1
|
LinBUT A81T
|
M1-1
|
T
|
A
|
I
|
A
|
I
|
A
|
M
|
92 ± 3
|
50
|
2.0 ± 1
|
0.2
|
This study
|
1
|
LinBUT A112V
|
M1-2
|
A
|
V
|
I
|
A
|
I
|
A
|
M
|
4 ± 0
|
2.1
|
0
|
0
|
This study
|
1
|
LinBUT I134V
|
M1-3
|
A
|
A
|
V
|
A
|
I
|
A
|
M
|
21 ± 0
|
11
|
5 ± 1
|
0.5
|
This studyb
|
1
|
LinBUT A135T
|
M1-4
|
A
|
A
|
I
|
T
|
I
|
A
|
M
|
23 ± 1
|
12
|
6 ± 2
|
0.6
|
This study
|
1
|
LinBUT I138L
|
M1-5
|
A
|
A
|
I
|
A
|
L
|
A
|
M
|
35 ± 1
|
18
|
5 ± 1
|
0.5
|
This study
|
1
|
LinBUT A247H
|
M1-6
|
A
|
A
|
I
|
A
|
I
|
H
|
M
|
68 ± 2
|
36
|
4 ± 1
|
0.4
|
This studyb
|
1
|
LinBUT M253I
|
M1-7
|
A
|
A
|
I
|
A
|
I
|
A
|
I
|
39 ± 1
|
21
|
4 ± 1
|
0.4
|
This study
|
2
|
LinBUT I134V/A247H
|
M2-1
|
A
|
A
|
V
|
A
|
I
|
H
|
M
|
30 ± 0
|
16
|
7 ± 1
|
0.7
|
This studyb
|
3
|
LinBUT A112V/ I134V/A247H
|
M3-1
|
A
|
V
|
V
|
A
|
I
|
H
|
M
|
53 ± 3
|
28
|
17 ± 2
|
1.7
|
This study
|
3
|
LinBUT I134V/I138L/A247H
|
M3-2
|
A
|
A
|
V
|
A
|
L
|
H
|
M
|
69 ± 10
|
36
|
31 ± 7
|
3.1
|
This study
|
3
|
LinBUT I134V/A247H/M253I
|
M3-3
|
A
|
A
|
V
|
A
|
I
|
H
|
I
|
33 ± 1
|
17
|
7 ± 1
|
0.7
|
This study
|
4
|
LinBUT A112V/I134V/I138L/A247H
|
M4-1
|
A
|
V
|
V
|
A
|
L
|
H
|
M
|
48 ± 4
|
25
|
85 ± 10
|
8.5
|
This study
|
4
|
LinBUT I134V/I138L/A247H/M253I
|
M4-2
|
A
|
A
|
V
|
A
|
L
|
H
|
I
|
1.0 ± 0.2 x 102
|
53
|
83 ± 20
|
8.3
|
This study
|
5
|
LinBUT A112V/I134V/I138L/A247H/M253I
|
M5-1
|
A
|
V
|
V
|
A
|
L
|
H
|
I
|
1.2 ± 0.1 x 102
|
63
|
1.3 ± 0.2 x 102
|
13
|
This study
|
5
|
LinBUT A81T/I134V/I138L/A247H/M253I
|
M5-2
|
T
|
A
|
V
|
A
|
L
|
H
|
I
|
79 ± 10
|
42
|
50 ± 10
|
5
|
This study
|
5
|
LinBUT I134V/A135T/I138L/A247H/M253I
|
M5-3
|
A
|
A
|
V
|
T
|
L
|
H
|
I
|
68 ± 8
|
36
|
90 ± 20
|
9
|
This study
|
5
|
LinBUT A81T/A112V/I134V/I138L/A247H
|
M5-4
|
T
|
V
|
V
|
A
|
L
|
H
|
M
|
91 ± 9
|
48
|
83 ± 10
|
8.3
|
This study
|
5
|
LinBUT A112V/I134V/A135T/I138L/A247H
|
M5-5
|
A
|
V
|
V
|
T
|
L
|
H
|
M
|
84 ± 20
|
44
|
73 ± 20
|
7.3
|
This study
|
6
|
LinBMI T81A
|
M6-1
|
A
|
V
|
V
|
T
|
L
|
H
|
I
|
68 ± 3
|
36
|
9.5 ± 5.0 x 102
|
95
|
Okai et al. [2013]
|
6
|
LinBMI V112A
|
M6-2
|
T
|
A
|
V
|
T
|
L
|
H
|
I
|
1.0 ± 0.09 x 102
|
53
|
2.3 ± 0.4 x 102
|
23
|
Okai et al. [2013]
|
6
|
LinBMI V134I
|
M6-3
|
T
|
V
|
I
|
T
|
L
|
H
|
I
|
1.2 ± 0.05 x 102
|
63
|
80 ± 3
|
8
|
Ito et al. [2007]
|
6
|
LinBMI T135A
|
M6-4
|
T
|
V
|
V
|
A
|
L
|
H
|
I
|
83 ± 5
|
44
|
4.2 ± 1 x 102
|
42
|
Okai et al. [2013]
|
6
|
LinBMI L138I
|
M6-5
|
T
|
V
|
V
|
T
|
I
|
H
|
I
|
1.3 ± 0.1 x 102
|
68
|
2.2 ± 0.4 x 102
|
22
|
Okai et al. [2013]
|
6
|
LinBMI H247A
|
M6-6
|
T
|
V
|
V
|
T
|
L
|
A
|
I
|
2.1 ± 0.2 x 102
|
111
|
2.4 ± 0.2 x 102
|
24
|
Ito et al. [2007]
|
6
|
LinBMI I253M
|
M6-7
|
T
|
V
|
V
|
T
|
L
|
H
|
M
|
2.1 ± 0.3 x 102
|
111
|
1.4 ± 0.2 x 102
|
14
|
Okai et al. [2013]
|
7
|
LinBMI
| |
T
|
V
|
V
|
T
|
L
|
H
|
I
|
1.9 ± 0.08 x 102
|
100
|
1.0 ± 0.3 x 103
|
100
|
Okai et al. [2013]
|