Figure 1

Schematic diagram of the β-ketoadipate pathway (A) and distribution of pca gene clusters (B) in Corynebacterium glutamicum . (A). Descriptions and abbreviations: PcaHG, PCA 3, 4-dioxygenase; PcaB, β-carboxy-cis,cis- muconate cycloisomerase; PcaC, γ-carboxymuconolactone decarboxylase; PcaD, β-ketoadipate enol-lactone hydrolase; PcaIJ, β-ketoadipate:succinyl-coenzyme A transferase; PcaF, β-ketoadipate acetyl CoA acetyltransferase; TCA, tricarboxylic acid cycle. (B). Genes organized as an operon are shown in the same color. Arrows indicate transcriptional activation and repression (Shen et al. [2012]; Zhao et al. [2010]). Numbers above genes indicate expression ratios of H₂O₂-adapted strain/wild-type from transcriptome results using RNA-seq (NCBI Gene Expression Omnibus access code: GSE41232) (Lee et al. [2013b]).