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AMB Express

Table 3 Ergosterol content of CA04 cells treated with various concentrations of cinnamaldehyde and eugenol

From: Phenyl aldehyde and propanoids exert multiple sites of action towards cell membrane and cell wall targeting ergosterol in Candida albicans

Test compounds

Mean ergosterol content

0.25 × MIC

0.5 × MIC

1 × MIC

Cinnamaldehyde

0.0126 ± 0.001 (58.96)

0.0101 ± 0.001 (67.41)

0.0022 ± 0.0002 (92.84)

Eugenol

0.0124 ± 0.001 (59.61)

0.0073 ± 0.0004 (76.23)

0.0009 ± 0.00006 (97.07)

Fluconazole (control)

0.0257 ± 0.002 (16.29)

0.0197 ± 0.001 (35.81)

0.0118 ± 0.001 (61.57)

  1. Data are presented as a percentage of the wet weight of the cell ± SD, followed in parentheses by the reduction (%) in the mean cellular ergosterol content compared with that of untreated control cell.
  2. Value for untreated control cell was 0.0307 ± 0.003, considered as 100% ergosterol content in an untreated cell.
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