Phenyl aldehyde and propanoids exert multiple sites of action towards cell membrane and cell wall targeting ergosterol in Candida albicans

AMB Express

Table 1 Haemolytic property of cinnamaldehyde, eugenol and fluconazole

Test compounds	Percent haemolysis of RBC (Mean ± SD)
	Concentrations of compounds (μg/mL)
	18	36	72	144	288	576	1152	2304
Eugenol	1.65 ± 0.14	1.98 ± 0.09	3.02 ± 0.08	3.72 ± 0.16	4.26 ± 0.16	4.78 ± 0.25	5.60 ± 0.63	19.03 ± 0.30
Cinnamaldehyde	1.84 ± 0.19	2.87 ± 0.07	3.39 ± 0.12	3.96 ± 0.05	4.40 ± 0.17	5.06 ± 0.20	6.22 ± 0.19	18.11 ± 0.40
Antifungal drug	Concentrations of drug (μg/mL)
Antifungal drug	0.125	0.25	0.5	1.0	2.0	4.0	8.0	16.0
Amphotericin B	3.56 ± 1.11	8.64 ± 1.89	17.54 ± 2.67	22.45 ± 2.34	31.89 ± 3.22	39.39 ± 3.89	46.11 ± 2.23	58.11 ± 3.10

All the experiments were performed in triplicate and data is presented as mean ± SD.