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Table 1 Gene organization of bafilomycin biosynthetic gene cluster of Streptomyces griseus DSM 2608

From: Organization and characterization of a biosynthetic gene cluster for bafilomycin from Streptomyces griseus DSM 2608

ORF Gene product Number of amino acid Deduced function The closest gene Gene strain Homology (%)
(GenBank number)
ORF1 BafBI 460 acyl-CoA ligase (partial) ADC79613.1 Streptomyces lohii 93
ORF2 BafBII 513 amide synthetase ADC79614.1 Streptomyces lohii 96
ORF3 BafBIII 415 5-aminolevulinate synthase ADC79615.1 Streptomyces lohii 98
ORF4 BafSI 5016 modular polyketide synthase I ADC79616.1 Streptomyces lohii 93
ORF5 BafSII 5089 modular polyketide synthase II YP_004909056.1 Kitasatospora setae 85
ORF6 BafSIII 3981 modular polyketide synthase III ADC79618.1 Streptomyces lohii 94
ORF7 BafSIV 3627 modular polyketide synthase IV ADC79619.1 Streptomyces lohii 89
ORF8 BafSV 2106 modular polyketide synthase V ADC79620.1 Streptomyces lohii 93
ORF9 BafAI 297 3-hydroxyacyl-CoA dehydrogenase (NAD-dependent) ADC79621.1 Streptomyces lohii 97
ORF10 BafAII 94 acyl carrier protein ADC79622.1 Streptomyces lohii 97
ORF11 BafAIII 364 acyl-CoA dehydrogenases (FAD-dependent) ADC79623.1 Streptomyces lohii 98
ORF12 BafAIV 367 FkbH-like protein ADC79624.1 Streptomyces lohii 97
ORF13 BafAV 221 O-methyltransferase ADC79625.1 Streptomyces lohii 95
ORF14 BafRI 610 AfsR family transcriptional regulator ADC79626.1 Streptomyces lohii 96
ORF15 BafT 254 Thioesterase II ADC79627.1 Streptomyces lohii 95
ORF16 BafRII 118 LuxR-like protein ADC79628.1 Streptomyces lohii 91
ORF17 BafCII 321 malonyl transferase ADC79629.1 Streptomyces lohii 97
ORF18 BafCI 360 Putative CoA ligase ADC79630.1 Streptomyces lohii 97
ORF19   511 XRE family transcriptional regulator ZP_04709597.1 Streptomyces roseosporus 98
ORF20   506 2-methylcitrate reductase ZP_04709598.1 Streptomyces roseosporus 95
ORF21   379 methylcitrate synthase ZP_04709599.1 Streptomyces roseosporus 94
ORF22   224 GntR family transcriptional regulator ZP_11438254.1 Mycobacterium abscessus 53
ORF23   285 methylcitrate lyase ZP_04709600.1 Streptomyces roseosporus 91
ORF24   491 putative transcriptional regulator ZP_19189491.1 Streptomyces ipomoeae 71
ORF25   846 Osmosensitive K+ channel histidine kinase ZP_04995839.1 Streptomyces sp. Mg1 84
ORF26   225 K+-transporting ATPase subunit C ZP_04710866.1 Streptomyces roseosporus 82
ORF27   486 K+-transporting ATPase subunit B (partial) YP_001824190.1 Streptomyces griseus subsp. griseus 91