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Table 4 Inhibitory effects of CEN1 HC-Br, CEN1 HC, CEN1 HC (1–20) and CEN1 HC (Ser) on TNF-α and IL-6 secretion from THP-1 cells

From: Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis

  IC50(mg/L)
Test substance TNF-α IL-6
CEN1 HC-Br ~4.0 0.0040 ± 0.053
CEN1 HC 2.2 ± 0.4 0.33 ± 0.14
CEN1 HC (1–20) 141.4 ± 18.4 9.8 ± 8.6
CEN1 HC (Ser) 6.0 ± 2.4 nd
  1. Data are presented as half maximal inhibitory concentration (IC50) values ± SEM, as calculated by Origin software from dose–response curves using a 4-parameter fit. Due to an unsatisfactory curve fitting, IC50 for CEN1 HC-Br on TNF-α was estimated to approximately 4 mg/L. nd = not determined.