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Table 2 Microbicidal effect of CEN1 HC-Br, CEN1 HC, CEN1 HC-Br (1–20), CEN1 HC (1–20) and CEN1 HC (Ser) against S. aureus (a) and P. aeruginosa (b)

From: Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis

(a)  
  S. aureus, medium and MMC99 (mg/L)
Test substance 0.037% BHI 0.037% BHI + 85 mM NaCl 0.037% BHI + 150 mM NaCl 50% SWF
CEN1 HC-Br 25 25 50 50
CEN1 HC 12.5 25 50 25
CEN1 HC-Br (1–20) 12.5 >200 >200 >200
CEN1 HC (1–20) 12.5 >200 >200 >200
CEN1 HC (Ser) 25 >200 >200 >200
(b)     
  P. aeruginosa , medium and MMC 99 (mg/L)
Test substance 0.037% BHI 0.037% BHI + 85 mM NaCl 0.037% BHI + 150 mM NaCl 50% SWF
CEN1 HC-Br 25 12.5 25 100
CEN1 HC 12.5 12.5 12.5 100
CEN1 HC-Br (1–20) 12.5 12.5 25 >200
CEN1 HC (1–20) 12.5 25 100 >200
CEN1 HC (Ser) 12.5 25 50 >200
  1. The substances were tested using a MMC99 assay in concentrations up to 200 mg/L in four different assay media. Peptides were added to bacterial cells in duplicate (n = 2). Data are presented as maximum values from at least two independent experiments. h.i. = heat inactivated.
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