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Table 2 Microbicidal effect of CEN1 HC-Br, CEN1 HC, CEN1 HC-Br (1–20), CEN1 HC (1–20) and CEN1 HC (Ser) against S. aureus (a) and P. aeruginosa (b)

From: Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis

(a)

 
 

S. aureus, medium and MMC99 (mg/L)

Test substance

0.037% BHI

0.037% BHI + 85 mM NaCl

0.037% BHI + 150 mM NaCl

50% SWF

CEN1 HC-Br

25

25

50

50

CEN1 HC

12.5

25

50

25

CEN1 HC-Br (1–20)

12.5

>200

>200

>200

CEN1 HC (1–20)

12.5

>200

>200

>200

CEN1 HC (Ser)

25

>200

>200

>200

(b)

    
 

P. aeruginosa , medium and MMC 99 (mg/L)

Test substance

0.037% BHI

0.037% BHI + 85 mM NaCl

0.037% BHI + 150 mM NaCl

50% SWF

CEN1 HC-Br

25

12.5

25

100

CEN1 HC

12.5

12.5

12.5

100

CEN1 HC-Br (1–20)

12.5

12.5

25

>200

CEN1 HC (1–20)

12.5

25

100

>200

CEN1 HC (Ser)

12.5

25

50

>200

  1. The substances were tested using a MMC99 assay in concentrations up to 200 mg/L in four different assay media. Peptides were added to bacterial cells in duplicate (n = 2). Data are presented as maximum values from at least two independent experiments. h.i. = heat inactivated.