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Figure 3 | AMB Express

Figure 3

From: Metabolite proving fungal cleavage of the aromatic core part of a fluoroquinolone antibiotic

Figure 3

Metabolic scheme for PRA in G. striatum. Degradation routes were initiated by oxidative decarboxylation (A), defluorination (B), hydroxylation of position C-8 (C), and decomposition of the amine moiety (D) which, alternatively, could be eliminated intact as F-10. Hypothetical intermediates are marked in grey: twofold oxidation of the pyrogallol-type intermediate is likely to provide a cis,cis-muconic acid-type metabolite, from which F-13 may be formed after two spontaneous decarboxylations.

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