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Table 3 Analysis of Variance of quadratic model for bromelain production

From: Recombinant bromelain production in Escherichia coli: process optimization in shake flask culture by response surface methodology

Source

Sum of squares

F-value

P-value

Model

30.67

99.32

0.0001

Post-induction temperature, A

1.22

35.71

0.0001

Inducer concentration, B

1.52

44.34

0.0001

Post-induction period, C

0.016

0.47

0.5102

A2

2.01

58.54

0.0001

B2

1.57

45.64

0.0001

C2

0.70

20.41

0.0001

AB

5.61

163.56

0.0001

AC

3.25

94.77

0.0001

BC

2.53

73.78

0.0001

Lack of fit

0.21

1.54

0.3233

  1. R2 = 0.9889, adjusted R2 = 0.9790, C.V. = 2.32, adequate precision = 31.695