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Table 5 Effect of NFAT-133 and rosiglitazone on the body weight and liver weight in response to treatment in db/db mice

From: Fermentation, Isolation, Structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667

Group

% Change in body weight

% Change in liver weight

Vehicle

6.0 ± 0.6

2.3 ± 0.1

Rosiglitazone, 5 mg/kg, po

14.6 ± 0.8**

2.6 ± 0.1*

NFAT-133, 100 mg/kg, ip

-1.1 ± 1.2**

2.0 ± 0.1*

  1. Mice were treated for 10 days, bis in die (b.i.d) with vehicle, NFAT-133 [100 mg/kg, intra-peritoneal (i.p)] or rosiglitazone [5 mg/kg, per os (p.o.)]. The percent change in liver and bidy weight were measured after 10 days of treatment. All the results were expressed as Mean ± S.E.M. (n = 10). ** p < 0.01 and * p < 0.05 vs. day 0.
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