AMB Express

Table 2 Sequence variations of CYP102A1 variants^a

From: Characterization of diverse natural variants of CYP102A1 found within a species of Bacillus megaterium

	CYP102A1 Variants
	Mutated Amino acid	Change of Nucleotide	*2	*3	*4	*5	*6	*7	*8	*9	QMB1551
	T2P	4A > C									+
Heme domain	V27I	79G > A	+		+		+	+	+	+	+
	A29T	85G > A	+		+		+	+	+	+	+
	V128I	382G > A	+		+	+	+	+	+	+	+
	A136T	406G > A	+		+		+	+	+	+	+
	E208D	624A > C				+
	A222T	664G > A									+
	A296T	886G > A	+		+
	D370E	1110C > A	+		+
	K453Q	1357A > C				+	+	+	+	+	+
	T464R	1392T > A				+	+	+	+	+	+
	V471E	1413A > G				+	+	+	+	+	+
Reductase domain	K474T	1422G > C				+	+	+	+	+	+
	A475V	1424C > T	+	+	+	+	+	+	+	+	+
	Q513R	1539G > A						+
	R526P	1578C > T					+
	Q547E	1639C > G					+	+	+	+	+
	E559D	1677A > C	+	+	+
	L590F	1794C > A								+
	A591S	1771G > T				+
	D600E	1800C > A				+	+	+	+	+	+
	V625L	1873G > T				+	+	+	+	+	+
	D632N	1894G > A				+
	D638E	1914T > A					+	+	+	+	+
	K640A	1920A > T				+	+	+	+	+	+
	A652S	1954G > T									+
	G661R	1981G > C					+	+	+	+	+
	T665A	1993A > G	+	+	+	+	+	+	+	+	+
	Q675K	2023C > A					+	+	+	+	+
	P676L	2027C > T	+	+
	A679E	2036C > A	+	+	+
	E688A	2063A > C	+	+	+
	T716A	2146A > G					+	+	+	+	+
	A717T	2149G > A				+	+	+	+	+	+
	A742G	2225C > G	+	+	+	+	+	+	+	+	+
	A783V	2348C > T					+	+	+	+	+
	A796T	2386G > A				+
	K814E	2440A > G	+	+	+	+	+	+	+	+	+
	I825M	2474A > G				+	+	+	+	+	+
	R826S	2476C > A	+	+
	R837H	2510G > A	+	+
	E871N	2613G > T	+	+	+		+	+	+	+	+
	I882V	2644A > G	+	+	+	+	+	+	+	+	+
	E888G	2663A > G	+	+	+	+	+	+	+	+	+
	D894G	2681A > G					+	+	+	+	+
	P895S	2683C > T	+	+	+
	G913S	2739C > T			+
	E948K	2842G > A					+	+	+	+	+
	S955N	2864G > A	+	+	+	+	+	+	+	+	+
	M968V	2904G > A	+	+	+	+	+	+	+	+	+
	Q971E	2911C > G					+
	M980V	2938A > G				+
	Q982R	2945A > G	+	+
	A1009D	3026C > A	+	+	+	+	+	+	+	+	+
	D1020E	3060C > A				+	+	+	+	+	+
	H1022Y	3066C > T	+	+	+
	Q1023K	3067C > G				+
	Q1023E	3067C > A	+	+	+
	G1040S	3118G > A				+

^aVariations of amino acids and nucleotides in CYP102A1 variants (*2~*9) relative to CYP102A1.1 (P450 BM3) (*1) are shown by a (+) mark. Information regarding the CYP102A1 variant (designated as QMB1551) of B. megaterium QM B1551 (ATCC 12872) was obtained from the Whole Genome Sequencing of B. megaterium http://www.bios.niu.edu/b_megaterium/. We only used its genetic information to compare to those of other variants. Blanks mean no change of amino acids or nucleotides.

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